Thomas Keller Selected Research

N(4)- (2,2- dimethyl- 1- methylcarbamoylpropyl)- N(1)- hydroxy- 2- hydroxymethyl- 3- phenylsuccinamide

4/2002

Pharmacological profile of PKF242-484 and PKF241-466, novel dual inhibitors of TNF-alpha converting enzyme and matrix metalloproteinases, in models of airway inflammation.

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Thomas Keller Research Topics

Disease

12	Neoplasms (Cancer) 03/2020 - 03/2006
7	Breast Neoplasms (Breast Cancer) 07/2019 - 03/2006
6	Inflammation (Inflammations) 01/2022 - 04/2002
6	Neuroinflammatory Diseases 01/2022 - 08/2017
4	Melanoma (Melanoma, Malignant) 03/2020 - 10/2007
3	Prostatic Neoplasms (Prostate Cancer) 01/2022 - 03/2014
2	Myelitis 01/2022 - 01/2021
2	Alzheimer Disease (Alzheimer's Disease) 01/2022 - 08/2017
2	Pain (Aches) 10/2021 - 01/2019
2	Carcinogenesis 03/2020 - 08/2009
2	Pneumonia (Pneumonitis) 01/2020 - 04/2002
2	Malaria 01/2020 - 01/2019
2	Chronic Obstructive Pulmonary Disease (COPD) 01/2020 - 01/2020
2	Fatigue 12/2019 - 01/2014
2	Vomiting 08/2019 - 01/2015
2	Infections 08/2017 - 02/2010
2	Circulating Neoplastic Cells 02/2016 - 10/2014
2	Respiratory Tract Infections (Respiratory Tract Infection) 01/2016 - 01/2016
2	Neoplasm Metastasis (Metastasis) 01/2016 - 05/2011
2	Anorexia Nervosa 04/2007 - 11/2006
1	Vascular Remodeling 12/2022
1	Hyperalgesia 01/2022
1	Tachycardia (Tachyarrhythmias) 10/2021
1	Spinal Cord Injuries (Spinal Cord Injury) 01/2021
1	Squamous Cell Carcinoma of Head and Neck 01/2021
1	Head and Neck Neoplasms (Head and Neck Cancer) 01/2021
1	Asthma (Bronchial Asthma) 01/2020
1	Cerebral Malaria 01/2020
1	Hypoxia (Hypoxemia) 01/2020
1	Coma (Comas) 01/2020
1	Syndrome (Syndromes) 12/2019
1	Myoclonus (Nocturnal Myoclonus) 12/2019
1	Seizures (Absence Seizure) 12/2019
1	Sleepiness 12/2019
1	Dyspnea (Shortness of Breath) 12/2019
1	Nausea 12/2019
1	Colic (Abdominal Cramps) 08/2019
1	Hypesthesia (Numbness) 01/2019
1	Low Back Pain (Lumbago) 01/2019
1	Respiratory Insufficiency (Respiratory Failure) 01/2019

Drug/Important Bio-Agent (IBA)

11	Proteins (Proteins, Gene)FDA Link 01/2021 - 03/2006
9	Biomarkers (Surrogate Marker)IBA 01/2020 - 04/2007
5	Matrix Metalloproteinases (MMPs)IBA 03/2020 - 04/2002
4	Messenger RNA (mRNA)IBA 03/2020 - 10/2004
3	Prostate-Specific Antigen (Semenogelase)IBA 01/2022 - 01/2020
3	RNA (Ribonucleic Acid)IBA 03/2020 - 11/2017
3	Estrogen ReceptorsIBA 07/2019 - 03/2006
3	Transforming Growth Factor beta (TGF-beta)IBA 08/2009 - 01/2004
2	N,N- diethyl- 2- (2- (4- (2- fluoroethoxy)phenyl)- 5,7- dimethylpyrazolo(1,5- a)pyrimidin- 3- yl)acetamideIBA 01/2022 - 08/2017
2	Ephedrine FDA LinkGeneric 10/2021 - 01/2018
2	CytokinesIBA 01/2021 - 11/2006
2	LipidsIBA 03/2020 - 07/2013
2	AntioxidantsIBA 03/2020 - 08/2009
2	DNA (Deoxyribonucleic Acid)IBA 03/2020 - 01/2020
2	Vitamin D FDA LinkGeneric 03/2020 - 06/2012
2	Adrenal Cortex Hormones (Corticosteroids)IBA 01/2020 - 01/2020
2	human ERBB2 proteinIBA 07/2019 - 11/2017
2	Diphosphonates (Bisphosphonates)IBA 01/2016 - 03/2014
2	Pharmaceutical PreparationsIBA 01/2014 - 06/2007
2	carbohydrate-deficient transferrinIBA 04/2007 - 11/2006
1	CatecholaminesIBA 12/2022
1	(R)- (11C)1- (2- chlorophenyl)- N- methyl- N- (1- methylpropyl)- 3- isoquinolinecarboxamideIBA 01/2022
1	Buprenorphine (Subutex)FDA LinkGeneric 10/2021
1	Hydromorphone (Dilaudid)FDA LinkGeneric 10/2021
1	Methadone (Dolophine)FDA LinkGeneric 10/2021
1	Interleukin 1 Receptor Antagonist Protein (Anakinra)FDA Link 01/2021
1	acetamideIBA 01/2021
1	Interleukin-1 Receptors (Interleukin 1 Receptor)IBA 01/2021
1	Superoxide DismutaseIBA 03/2020
1	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 03/2020
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 03/2020
1	Interleukin-1 (Interleukin 1)IBA 03/2020
1	Reactive Oxygen Species (Oxygen Radicals)IBA 03/2020
1	Environmental Pollutants (Pollutants, Environmental)IBA 03/2020
1	Transforming Growth Factors (Transforming Growth Factor)IBA 03/2020
1	Nitric Oxide (Nitrogen Monoxide)FDA Link 01/2020
1	GoldIBA 01/2020
1	Oxygen (Dioxygen)IBA 01/2020
1	Cell-Free Nucleic AcidsIBA 01/2020
1	Cathepsin DIBA 01/2020
1	Simethicone FDA Link 08/2019
1	Phenobarbital (Luminal)FDA Link 07/2019
1	Biological ProductsIBA 01/2019
1	HLA-DR Antigens (HLA-DR)IBA 01/2019
1	Tapentadol FDA Link 01/2019
1	Drug CombinationsIBA 01/2019
1	4-amino-4'-hydroxylaminodiphenylsulfone (HADS)IBA 01/2019
1	Opioid Analgesics (Opioids)IBA 01/2019
1	Pregabalin (Lyrica)FDA Link 01/2019
1	propylene diquat (PDQ(+))IBA 01/2019
1	theodrenaline drug combination cafedrineIBA 01/2018

Therapy/Procedure

12	Therapeutics 01/2021 - 03/2006
2	Radiotherapy 01/2021 - 01/2016
2	Drug Therapy (Chemotherapy) 07/2019 - 03/2006
2	Aftercare (After-Treatment) 02/2016 - 01/2016
1	Transplantation 01/2021
1	Nebulizers and Vaporizers (Inhaler) 01/2020
1	Palliative Care (Palliative Therapy) 12/2019
1	Critical Care (Surgical Intensive Care) 12/2019
1	Analgesia 01/2019